ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Synthesis and biological evaluation of mannose-6-phosphate-coated multivalent dendritic cluster glycosides

Srinivas, Oruganti and Radhika, S and Bandaru, Narasimha Murthy and Nadimpalli, Siva Kumar and Jayaraman, Narayanaswamy (2005) Synthesis and biological evaluation of mannose-6-phosphate-coated multivalent dendritic cluster glycosides. In: Organic & Biomolecular Chemistry, 3 (23). pp. 4252-4257.

[img]
Preview
PDF
pv24.pdf

Download (416Kb)

Abstract

The synthesis of multivalent dendritic cluster glycosides of mannopyranosyl-6-phosphate is presented. Poly( amido amine)-based dendrimers of 0.5-3.5 generations, containing carboxylic acid peripheral functionalities, were utilized so as to install 4, 8, 16 and 32 mannopyranosyl-6-phosphate residues at the peripheries of the dendrimers. Amide bond formation between an amine-tethered mannopyranosyl-6-phosphate monomer unit and carboxylic acid-functionalized dendrimers was conducted to synthesize the dendritic cluster glycosides. The constitutions of the Man-6-P-containing dendrimers were assessed by $^{1}H, ^{13}C$ and $^{31}P$ NMR spectroscopies and the sugar content analysis by a resorcinol assay. Preliminary biological studies with few newly synthesized Man-6-P-containing dendrimers showed that these compounds could bind the purified goat liver mannose 6-phopshate receptor (MPR 300) protein.

Item Type: Journal Article
Additional Information: Copyright for this article belongs to Royal Society of Chemistry.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 16 Dec 2005
Last Modified: 19 Sep 2010 04:22
URI: http://eprints.iisc.ernet.in/id/eprint/4680

Actions (login required)

View Item View Item