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Bactericidal/permeability increasing protein: A multifaceted protein with functions beyond LPS neutralization

Balakrishnan, Arjun and Marathe, Sandhya A and Joglekar, Madhura and Chakravortty, Dipshikha (2013) Bactericidal/permeability increasing protein: A multifaceted protein with functions beyond LPS neutralization. In: INNATE IMMUNITY, 19 (4). pp. 339-347.

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Official URL: http://dx.doi.org/ 10.1177/1753425912465098

Abstract

Bactericidal permeability increasing protein (BPI), a 55-60kDa protein, first reported in 1975, has gone a long way as a protein with multifunctional roles. Its classical role in neutralizing endotoxin (LPS) raised high hopes among septic shock patients. Today, BPI is not just a LPS-neutralizing protein, but a protein with diverse functions. These functions can be as varied as inhibition of endothelial cell growth and inhibition of dendritic cell maturation, or as an anti-angiogenic, chemoattractant or opsonization agent. Though the literature available is extremely limited, it is fascinating to look into how BPI is gaining major importance as a signalling molecule. In this review, we briefly summarize the recent research focused on the multiple roles of BPI and its use as a therapeutic.

Item Type: Journal Article
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Additional Information: Copyright of this article is belongs to SAGE PUBLICATIONS
Keywords: Bactericidal; permeability increasing protein (BPI); antimicrobial peptides; PLUNC proteins; endotoxic shock; Gram-negative bacteria
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Other Centres/Units/UG Programme > Centre for Infectious Disease Research and Biosafety Laboratories
Date Deposited: 03 Sep 2013 08:50
Last Modified: 03 Sep 2013 11:37
URI: http://eprints.iisc.ernet.in/id/eprint/47030

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