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Physical understanding of pore formation on supported lipid bilayer by bacterial toxins

Bhattacharya, R and Agrawal, A and Ayappa, KG and Visweswariah, SS and Basu, JK (2012) Physical understanding of pore formation on supported lipid bilayer by bacterial toxins. In: Solid State Physics: Proceedings of the 57th DAE Solid State Physics Symposium 2012, Feb, 2013.

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Official URL: http://dx.doi.org/10.1063/1.4790958

Abstract

Pore forming toxins are being classified in the protein community based on their ability of forming pores in living cell membranes. Some initial study has apparently pointed out the crystallographic pathway rather can be viewed as a structural as well as morphological changes of proteins in terms of self assembly before and during the pore formation process in surfactant medium. Being a water soluble compound, it changes its conformation and originates some pre-pore complex, which later partially goes inside the cell membrane causing a pore. The physical mechanism for this whole process is still unknown. In this study we have tried to understand these types of biological processes from physical point of view by using supported lipid bilayer as a model system.

Item Type: Conference Paper
Additional Information: Copyright of this article belongs to American Institute of Physics.
Keywords: Biomembranes; Cellular Biophysics; Crystallography; Lipid Bilayers; Microorganisms; Molecular Biophysics; Proteins; Surfactants; Proteins; Biomolecules: Structure and Physical Properties; Membranes Bilayers and Vesicles
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 10 Feb 2014 10:22
Last Modified: 10 Feb 2014 10:22
URI: http://eprints.iisc.ernet.in/id/eprint/48348

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