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Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point

Bose, Tanima and Latawiec, Diane and Mondal, Partha Pratim and Mandal, Subhra (2014) Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point. In: JOURNAL OF NANOPARTICLE RESEARCH, 16 (8).

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Official URL: http://dx.doi.org/ 10.1007/s11051-014-2527-7

Abstract

The ever-increasing number of diseases worldwide requires comprehensive, efficient, and cost-effective modes of treatments. Among various strategies, nanomaterials fulfill most of these criteria. The unique physicochemical properties of nanoparticles have made them a premier choice as a drug or a drug delivery system for the purpose of treatment, and as bio-detectors for disease prognosis. However, the main challenge is the proper consideration of the physical properties of these nanomaterials, while developing them as potential tools for therapeutics and/or diagnostics. In this review, we focus mainly on the characteristics of nanoparticles to develop an effective and sensitive system for clinical purposes. This review will present an overview of the important properties of nanoparticles, through their journey from its route of administration until disposal from the human body after accomplishing targeted functionality. We have chosen cancer as our model disease to explain the potentiality of nano-systems for therapeutics and diagnostics in relation to several organs (intestine, lung, brain, etc.). Furthermore, we have discussed their biodegradability and accumulation probability which can cause unfavorable side effects in healthy human subjects.

Item Type: Journal Article
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Additional Information: Copy right for this article belongs to the SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
Department/Centre: Others
Date Deposited: 26 Aug 2014 06:27
Last Modified: 26 Aug 2014 06:27
URI: http://eprints.iisc.ernet.in/id/eprint/49666

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