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$^7Li and ^{23}Na$ NMR studies of transmembrane cation transport mediated by ionophore lasalocid A

Juvvadi, Padmaja and Kalapaty, Easwaran (1998) $^7Li and ^{23}Na$ NMR studies of transmembrane cation transport mediated by ionophore lasalocid A. In: Journal of Peptide Science, 4 (1). pp. 15-20.

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Abstract

Ion transport across phospholipid vesicles was studied by $^7Li and ^{23}Na$ -NMR using an aqueous anionic paramagnetic shift reagent, dysprosium nitrilotriacetate $[Dy(NTA)_2]^{3-}$, mediated by ionophores, lasalocid A and A23187. The intra- and extracellular $^7Li and ^{23}Na$ -NMR signals were well separated (20 Hz) at mM concentration of the shift reagent. The observed data on the rate constant for lithium transport across DPPC vesicles at various concentrations of the ionophores indicated that lasalocid A is a more efficient carrier for lithium ion compared with the sodium ion transport by this ionophore, while A23187 was not specific to either of the ions (Li or Na).

Item Type: Journal Article
Additional Information: The copyright belongs to European Peptide Society and John Wiley & Sons, Ltd.
Keywords: ion transport;kinetics;lithium;nmr;shift reagent;vesicles
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 16 Jan 2006
Last Modified: 27 Aug 2008 11:40
URI: http://eprints.iisc.ernet.in/id/eprint/4994

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