Lal, Girdhari and Shaila, MS and Nayak, Rabindranath (2006) Idiotypic T cells specific for Morbillivirus nucleocapsid protein process and present their TCR to cognate anti-idiotypic $CD8^+ T$ cells. In: Immunology Letters, 102 (2). pp. 132-140.
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$CD8^+ T$ cells are activated by the presentation of antigenic peptide through MHC class I molecules. Newly synthesized proteins formed as defective ribosomal products (DRiPs) can act as a major source of antigenic peptides for MHC class I presentation pathway. Majority of these peptides are generated from the intracellular degradation of self antigens. In the present study, we have shown that newly synthesized T cell receptor (TCR) beta chains formed as DRiPs in T cells are ubiquitinated and degraded by the proteasomes. These TCR-DRiPs are processed and presented by activated T cells to cognate anti-idiotypic $CD8^+ T$ cells. Presentation of TCR idiopeptide (peptide derived from the variable region of idiotypic TCR) by activated T cells leads to Bcl-2 expression and cytokine secretion by anti-idiotypic $CD8^+ T$ cells. Presentation of intracellular antigen by T cells may have important implications in immunoregulation, control of lymphotropic virus infection and autoimmune diseases.
|Item Type:||Journal Article|
|Additional Information:||The Copyright belongs to Elsevier BV.|
|Keywords:||T-APC;Proteasome;DRiPs;Anti-idiotypic T cells|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology|
|Date Deposited:||20 Jan 2006|
|Last Modified:||19 Sep 2010 04:22|
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