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Remotely triggered micro-shock wave responsive drug delivery system for resolving diabetic wound infection and controlling blood sugar levels

Gnanadhas, Divya Prakash and Elango, Monalisha and Ben Thomas, Midhun and Gopalan, Jagadeesh and Chakravortty, Dipshikha (2015) Remotely triggered micro-shock wave responsive drug delivery system for resolving diabetic wound infection and controlling blood sugar levels. In: RSC ADVANCES, 5 (17). pp. 13234-13238.

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Official URL: http://dx.doi.org/ 10.1039/c4ra15270k

Abstract

A novel, micro-shock wave responsive spermidine and dextran sulfate microparticle was developed. Almost 90% of the drug release was observed when the particles were exposed to micro-shock waves 5 times. Micro-shock waves served two purposes; of releasing the antibiotic from the system and perhaps disrupting the S. aureus biofilm in the skin infection model. A combination of shock waves with ciprofloxacin loaded microparticles could completely cure the S. aureus infection lesion in a diabetic mouse model. As a proof of concept insulin release was triggered using micro-shock waves in diabetic mice to reduce the blood glucose level. Insulin release could be triggered for at least 3 days by exposing subcutaneously injected insulin loaded particles.

Item Type: Journal Article
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Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Mechanical Sciences > Aerospace Engineering (Formerly, Aeronautical Engineering)
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Date Deposited: 19 Mar 2015 12:11
Last Modified: 19 Mar 2015 12:11
URI: http://eprints.iisc.ernet.in/id/eprint/51064

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