Gnanadhas, Divya Prakash and Elango, Monalisha and Ben Thomas, Midhun and Gopalan, Jagadeesh and Chakravortty, Dipshikha (2015) Remotely triggered micro-shock wave responsive drug delivery system for resolving diabetic wound infection and controlling blood sugar levels. In: RSC ADVANCES, 5 (17). pp. 13234-13238.
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A novel, micro-shock wave responsive spermidine and dextran sulfate microparticle was developed. Almost 90% of the drug release was observed when the particles were exposed to micro-shock waves 5 times. Micro-shock waves served two purposes; of releasing the antibiotic from the system and perhaps disrupting the S. aureus biofilm in the skin infection model. A combination of shock waves with ciprofloxacin loaded microparticles could completely cure the S. aureus infection lesion in a diabetic mouse model. As a proof of concept insulin release was triggered using micro-shock waves in diabetic mice to reduce the blood glucose level. Insulin release could be triggered for at least 3 days by exposing subcutaneously injected insulin loaded particles.
|Item Type:||Journal Article|
|Additional Information:||Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND|
|Department/Centre:||Division of Biological Sciences > Microbiology & Cell Biology
Division of Mechanical Sciences > Aerospace Engineering (Formerly, Aeronautical Engineering)
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
|Date Deposited:||19 Mar 2015 12:11|
|Last Modified:||19 Mar 2015 12:11|
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