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Photonic monitoring of chitosan nanostructured alginate microcapsules for drug release

Khajuria, Deepak Kumar and Konnur, Manish C and Vasireddi, Ramakrishna and Mahapatra, Roy D (2015) Photonic monitoring of chitosan nanostructured alginate microcapsules for drug release. In: PHOTONIC THERAPEUTICS AND DIAGNOSTICS XI, FEB 07-08, 2015, San Francisco, CA.

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Official URL: http://dx.doi.org/ 10.1117/12.2084966

Abstract

By using a novel microfluidic set-up for drug screening applications, this study examines delivery of a novel risedronate based drug formulation for treatment of osteoporosis that was developed to overcome the usual shortcomings of risedronate, such as its low bioavailability and adverse gastric effects. Risedronate nanoparticles were prepared using muco-adhesive polymers such as chitosan as matrix for improving the intestinal cellular absorption of risedronate and also using a gastric-resistant polymer such as sodium alginate for reducing the gastric inflammation of risedronate. The in-vitro characteristics of the alginate encapsulated chitosan nanoparticles are investigated, including their stability, muco-adhesiveness, and Caco-2 cell permeability. Fluorescent markers are tagged with the polymers and their morphology within the microcapsules is imaged at various stages of drug release.

Item Type: Conference Proceedings
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Additional Information: Copy right for this article belongs to the SPIE-INT SOC OPTICAL ENGINEERING, 1000 20TH ST, PO BOX 10, BELLINGHAM, WA 98227-0010 USA
Keywords: Sodium alginate; chitosan; risedronate sodium; osteoporosis; microfluidic device; drug delivery system
Department/Centre: Division of Mechanical Sciences > Aerospace Engineering (Formerly, Aeronautical Engineering)
Date Deposited: 22 Jun 2015 06:51
Last Modified: 22 Jun 2015 06:51
URI: http://eprints.iisc.ernet.in/id/eprint/51742

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