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Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters

Dasgupta, Queeny and Chatterjee, Kaushik and Madras, Giridhar (2015) Controlled Release of Salicylic Acid from Biodegradable Cross-Linked Polyesters. In: MOLECULAR PHARMACEUTICS, 12 (9). pp. 3479-3489.

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Official URL: http://dx.doi.org/10.1021/acs.molpharmaceut.5b0051...

Abstract

The purpose of this work was to develop a family of crosslinked poly(xylitol adipate salicylate)s with a wide range of tunable release properties for delivering pharmacologically active salicylic acid. The synthesis parameters and release conditions were varied to modulate polyester properties and to understand the mechanism of release. Varying release rates were obtained upon longer curing (35% in the noncured polymer to 10% in the cured polymer in 7 days). Differential salicylic acid loading led to the synthesis of polymers with variable cross-linking and the release could be tuned (100% release for the lowest loading to 30% in the highest loading). Controlled release was monitored by changing various factors, and the release profiles were dependent on the stoichiometric composition, pH, curing time, and presence of enzyme. The polymer released a combination of salicylic acid and disalicylic acid, and the released products were found to be nontoxic. Minimal hemolysis and platelet activation indicated good blood compatibility. These polymers qualify as ``bioactive'' and ``resorbable'' and can, therefore, find applications as immunomodulatory resorbable biomaterials with tunable release properties.

Item Type: Journal Article
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Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Keywords: polyester; salicylic acid; controlled release; biodegradable polymers
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Others
Date Deposited: 09 Oct 2015 04:34
Last Modified: 09 Oct 2015 04:34
URI: http://eprints.iisc.ernet.in/id/eprint/52509

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