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Ru (II)-Catalyzed C-H Activation: Ketone-Directed Novel 1,4-Addition of Ortho C-H Bond to Maleimides

Bettadapur, Kiran R and Lanke, Veeranjaneyulu and Prabhu, Kandikere Ramaiah (2015) Ru (II)-Catalyzed C-H Activation: Ketone-Directed Novel 1,4-Addition of Ortho C-H Bond to Maleimides. In: ORGANIC LETTERS, 17 (19). pp. 4658-4661.

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Official URL: http://dx.doi.org/10.1021/acs.orglett.5b01810

Abstract

A 1,4-addition with the nucleophilic center generated at the ortho carbon atom of an aromatic ketone in the presence of the highly reactive alpha-C-H bond, using a directing group strategy, is presented. The reaction yields pharmaceutically useful 3-arylated succinimide derivatives. In order to gain understanding of this redox neutral reaction, despite the presence of copper acetate, and to substantiate the lack of Heck-type products, DFT calculations have been carried out.

Item Type: Journal Article
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Additional Information: Copy right for this article belongs to the AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 05 Nov 2015 06:53
Last Modified: 05 Nov 2015 06:53
URI: http://eprints.iisc.ernet.in/id/eprint/52679

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