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Peptide delta-Turn: Literature Survey and Recent Progress

Toniolo, Claudio and Crisma, Marco and Moretto, Alessandro and Peggion, Cristina and Formaggio, Fernando and Aleman, Carlos and Cativiela, Carlos and Ramakrishnan, Chandrasekharan and Balaram, Padmanabhan (2015) Peptide delta-Turn: Literature Survey and Recent Progress. In: CHEMISTRY-A EUROPEAN JOURNAL, 21 (40). pp. 13866-13877.

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Official URL: http://dx.doi.org/10.1002/chem.201501467

Abstract

Among the various types of a-peptide folding motifs, delta-turn, which requires a central cis-amide disposition, has been one of the least extensively investigated. In particular, this main-chain reversal topology has been studied in-depth neither in linear/cyclic peptides nor in proteins. This Minireview article assembles and critically analyzes relevant data from a literature survey on the d-turn conformation in those compounds. Unpublished results from recent conformational energy calculations and a preliminary solution-state analysis on a small model peptide, currently ongoing in our laboratories, are also briefly outlined.

Item Type: Journal Article
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Additional Information: Copy right for this article belongs to the WILEY-V C H VERLAG GMBH, POSTFACH 101161, 69451 WEINHEIM, GERMANY
Keywords: cis-amide; conformational analysis; peptides; statistical analysis; X-ray diffraction
Department/Centre: Division of Biological Sciences > Molecular Biophysics Unit
Date Deposited: 19 Nov 2015 04:55
Last Modified: 19 Nov 2015 04:55
URI: http://eprints.iisc.ernet.in/id/eprint/52774

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