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HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection

Ahmed, A and Rakshit, S and Vyakarnam, A (2016) HIV-TB co-infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection. In: 7th World Workshop on Oral Health and Disease in AIDS, NOV 06-09, 2014, Hyderabad, INDIA, pp. 53-60.

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Official URL: http://dx.doi.org/10.1111/odi.12390

Abstract

HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system principally by killing and altering CD4 T-cell function. How HIV infection disrupts CD4 T-cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine- or immune-based strategies to control and monitor TB in HIV-infected subjects. This review considers key pathways that are altered in HIV-infected subjects that impair anti-TB immunity.

Item Type: Conference Proceedings
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Additional Information: Copy right for this article belongs to the WILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
Keywords: Tuberculosis; HIV; CD4 T cell; Interferon; reactivation
Department/Centre: Other Centres/Units/UG Programme > Centre for Infectious Disease Research and Biosafety Laboratories
Date Deposited: 15 Jun 2016 05:22
Last Modified: 15 Jun 2016 05:22
URI: http://eprints.iisc.ernet.in/id/eprint/53912

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