Ramesh, R and Chandrasekaran, S (2005) But-2-ynylbisoxycarbonyl Chloride: A Novel $C_2$-Symmetric Reagent for the Protection of Amines and Amino Acids. In: Organic Letters, 7 (22). pp. 4947-4950.
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A novel $C_2$-symmetric protecting group for amines, the but-2-ynylbisoxycarbonyl (Bbc) group, is developed, which can be deblocked with tetrathiomolybdate under neutral conditions. One equivalent of the bischloroformate, BbcCl, is used for the protection of 2 equiv of the amine. Its application in peptide synthesis is established through the synthesis of a tripeptide, and its orthogonality with Cbz, Fmoc, and Boc groups has been studied.
|Item Type:||Journal Article|
|Additional Information:||The copyright belongs to American Chemical Society.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||20 Feb 2006|
|Last Modified:||19 Sep 2010 04:23|
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