ePrints@IIScePrints@IISc Home | About | Browse | Latest Additions | Advanced Search | Contact | Help

Synthesis, Crystal and Molecular Structure of Boc-Pro- \bigtriangleup Phe- Ala- \bigtriangleup Phe- Ala-OMe ; A Pentapeptide with a Novel \beta -Bend Ribbon Structure

Rajashankar, Kanagalaghatta Ramabhatta and Ramakumar, Suryanarayanarao and Mal, Tapas Kumar and Chauhan, Virander Singh (1994) Synthesis, Crystal and Molecular Structure of Boc-Pro- \bigtriangleup Phe- Ala- \bigtriangleup Phe- Ala-OMe ; A Pentapeptide with a Novel \beta -Bend Ribbon Structure. In: Angewandte Chemie International Edition in English, 33 (9). pp. 970-973.

[img] PDF
page192.pdf
Restricted to Registered users only

Download (512Kb) | Request a copy

Abstract

\alpha, \beta -Dehydroamino acid residues (2,3-didehydroamino acid residues) are found in several naturally occurring peptides from microbial sources as well as in some proteins;[1] their presence in a peptide chain produces remarkable conformational consequences.[2] In addition, dehydropeptides show enhanced resistance to enzymatic degradation.[3] Thus, introduction of \alpha, \beta -de-hydroamino acid residues into bioactive peptide sequences has become an important tool to study structure-function relationships, and to provide analogues of peptide hormones with improved bioactivity.[4]

Item Type: Journal Article
Additional Information: The copyright belongs to VCH Verlagsgesellschaft mbH, Weinheim.
Department/Centre: Division of Physical & Mathematical Sciences > Physics
Date Deposited: 27 Feb 2006
Last Modified: 19 Sep 2010 04:23
URI: http://eprints.iisc.ernet.in/id/eprint/5585

Actions (login required)

View Item View Item