Rajashankar, Kanagalaghatta Ramabhatta and Ramakumar, Suryanarayanarao and Mal, Tapas Kumar and Chauhan, Virander Singh (1994) Synthesis, Crystal and Molecular Structure of Boc-Pro- \bigtriangleup Phe- Ala- \bigtriangleup Phe- Ala-OMe ; A Pentapeptide with a Novel \beta -Bend Ribbon Structure. In: Angewandte Chemie International Edition in English, 33 (9). pp. 970-973.
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\alpha, \beta -Dehydroamino acid residues (2,3-didehydroamino acid residues) are found in several naturally occurring peptides from microbial sources as well as in some proteins; their presence in a peptide chain produces remarkable conformational consequences. In addition, dehydropeptides show enhanced resistance to enzymatic degradation. Thus, introduction of \alpha, \beta -de-hydroamino acid residues into bioactive peptide sequences has become an important tool to study structure-function relationships, and to provide analogues of peptide hormones with improved bioactivity.
|Item Type:||Journal Article|
|Additional Information:||The copyright belongs to VCH Verlagsgesellschaft mbH, Weinheim.|
|Department/Centre:||Division of Physical & Mathematical Sciences > Physics|
|Date Deposited:||27 Feb 2006|
|Last Modified:||19 Sep 2010 04:23|
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