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Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents

Tiwary, C S and Mudakavi, Rajeev J and Kishore, Sharan and Kashyap, Sanjay and Elumalai, Rajasegaran and Chakravortty, Dipshikha and Raichur, Ashok M and Chattopadhyay, K (2016) Magnetic iron nanoparticles for in vivo targeted delivery and as biocompatible contrast agents. In: RSC ADVANCES, 6 (115). pp. 114344-114352.

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Official URL: http://dx.doi.org/10.1039/c6ra14817d

Abstract

Iron nanoparticles (NPs) of size less than 20 nm were synthesized using an in-house developed cryomill. These NPs exhibit values of saturation magnetisation (similar to 180 emu g(-1)) close to that of pure iron. The particles were found to be nontoxic at concentrations required for MRI imaging as indicated by MTT assay. In vivo studies demonstrated the suitability of using these particles as contrast agents for MRI. The iron NPs were bio-capped with TRITC-dextran and injected into mice to study the transport behavior of the NPs under the influence of an external magnetic field. The iron NPs showed enhanced aggregation and contrast when a bar magnet was placed on the mice as observed by whole body fluorescence imaging.

Item Type: Journal Article
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Additional Information: Copy right for this article belongs to the ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
Department/Centre: Division of Biological Sciences > Microbiology & Cell Biology
Division of Mechanical Sciences > Materials Engineering (formerly Metallurgy)
Others
Date Deposited: 18 Feb 2017 04:59
Last Modified: 18 Feb 2017 04:59
URI: http://eprints.iisc.ernet.in/id/eprint/56276

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