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Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat

Rajmani, RS and Singh, Prafull and Singh, Lakshya Veer (2017) Apoptotic and Immunosuppressive Effects of Turmeric Paste on 7, 12 Di Methyl Benz (a) Anthracene Induced Skin Tumor Model of Wistar Rat. In: NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 69 (8). pp. 1245-1255.

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Official URL: http://dx.doi.org/10.1080/01635581.2017.1367933

Abstract

Dietary components with potent anticancerous property are gaining attention as therapeutic agents due to low cost of therapy and minimal toxic effects. Turmeric is one such miracle spices of Indian and South Asian recipes with multiple medicinal properties. The anticarcinogenic properties of its active compound curcumin have been studied in detail. However, studies on the medicinal properties of crude turmeric used as dietary agents are lacking. Therefore, in this study we investigated the effects of dietary and topical crude turmeric paste on DMBA induced skin tumor of male Wistar rats. We observed the apoptotic effect of crude turmeric paste on DMBA induced tumor with depletion of T cells response. Our results demonstrated the significant expression of major pro-apoptotic genes like caspase-2, 3, 8, 9, PARP, and p53 and down regulation of major pro-inflammatory (NF-B) and pro-angiogenic factors and (VEGF) in turmeric treated tumor tissues. We also observed significant decrease in CD4(+), CD8(+), and Natural Killer cell population as compared to the untreated group.

Item Type: Journal Article
Additional Information: Copy right for this article belongs to the ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD, 2-4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND
Department/Centre: ?? CIDRBL ??
Depositing User: Id for Latest eprints
Date Deposited: 27 Dec 2017 10:11
Last Modified: 27 Dec 2017 10:11
URI: http://eprints.iisc.ac.in/id/eprint/58561

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