Bhattacharya, Santanu and Sengupta, Saumitra (2004) Palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) in water. In: Tetrahedron Letters, 45 (47). pp. 8733-8736.
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The palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) has been achieved in pure water without any additives or phase transfer catalysts. The reaction, which requires only 0.5mol% of $Pd(PPh_3)_4$ catalyst, is remarkably fast (30min at $70^oC$) producing high yields of the aryl alkyne products.
|Item Type:||Journal Article|
|Additional Information:||The copyright of this article belongs to Elsevier.|
|Keywords:||Sonogashira reaction;Palladium;Water;Aryl halides;Alkynylation.|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||31 Mar 2006|
|Last Modified:||19 Sep 2010 04:25|
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