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Palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) in water

Bhattacharya, Santanu and Sengupta, Saumitra (2004) Palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) in water. In: Tetrahedron Letters, 45 (47). pp. 8733-8736.

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Abstract

The palladium catalyzed alkynylation of aryl halides (Sonogashira reaction) has been achieved in pure water without any additives or phase transfer catalysts. The reaction, which requires only 0.5mol% of $Pd(PPh_3)_4$ catalyst, is remarkably fast (30min at $70^oC$) producing high yields of the aryl alkyne products.

Item Type: Journal Article
Additional Information: The copyright of this article belongs to Elsevier.
Keywords: Sonogashira reaction;Palladium;Water;Aryl halides;Alkynylation.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 31 Mar 2006
Last Modified: 19 Sep 2010 04:25
URI: http://eprints.iisc.ernet.in/id/eprint/6152

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