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A mild and selective method for N-dealkylation of tertiary amines

Bhat, Ramakrishna G and Ghosh, Yagnaseni and Chandrasekaran, Srinivasan (2004) A mild and selective method for N-dealkylation of tertiary amines. In: Tetrahedron Letters, 45 (43). pp. 7983-7985.

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Abstract

Alkyl groups can be cleaved e.ciently and selectively from tertiary alkyl amines using propargyl chloroformate. The propargyloxycarbonyl (Poc) protected secondary amines thus obtained can be deblocked under neutral and mild conditions using benzyltriethylammonium tetrathiomolybdate. The generality and compatibility of the method have been studied with a wide range of functionalities.

Item Type: Journal Article
Additional Information: The copyright of this article belongs to Elsevier.
Keywords: N-Dealkylation;Propargyl chloroformate;Tetrathiomolybdate.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 10 Apr 2006
Last Modified: 19 Sep 2010 04:25
URI: http://eprints.iisc.ernet.in/id/eprint/6180

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