Nandi, Dipankar and Tahiliani, Pankaj and Kumar, Anujith and Chandu, Dilip (2006) The ubiquitin-proteasome system. In: Journal of Biosciences, 31 (1). pp. 137-155.
The 2004 Nobel Prize in chemistry for the discovery of protein ubiquitination has led to the recognition of cellular proteolysis as a central area of research in biology. Eukaryotic proteins targeted for degradation by this pathway are first ‘tagged’ by multimers of a protein known as ubiquitin and are later proteolyzed by a giant enzyme known as the proteasome. This article recounts the key observations that led to the discovery of ubiquitin-proteasome system (UPS). In addition, different aspects of proteasome biology are highlighted. Finally, some key roles of the UPS in different areas of biology and the use of inhibitors of this pathway as possible drug targets are discussed.
|Item Type:||Journal Article|
|Additional Information:||Copyright for this article belongs to Indian Academy of Sciences.|
|Keywords:||Cellular proteolysis;Proteasomes;Protein degradation;Ubiquitination.|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||18 Dec 2006|
|Last Modified:||19 Sep 2010 04:25|
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