Ghosal, Gargi and Muniyappa, K (2006) Hoogsteen base-pairing revisited: Resolving a role in normal biological processes and human diseases. In: Biochemical and Biophysical Research Communications, 343 (1). pp. 1-7.
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For a long time since the discovery of an alternative type of hydrogen bonding between adenine and thymidine, termed Hoogsteen base-pairing, its biological role remained elusive. Recent experiments provide compelling evidence that Hoogsteen base pairs manifest in a gamut of nuclear processes encompassing gene expression, replication, recombination, and telomere length maintenance. An increasing number of proteins that have been shown to bind, unwind or cleave G-quadruplexes or triplexes with high specificity underscore their biological significance. In humans, the absence of these cellular factors or their dysfunction leads to a wide spectrum of genetic diseases including cancer, neurodegenerative syndromes, and a myriad of other disorders. Thus, development of clinically useful compounds that target G-quadruplexes or triplexes, and interfere with specific cellular processes, provides considerable promise for successful and improved treatment of human diseases.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||Hoogsteen base-pairing;DNA transactions;G-quadruplexes;RecQ helicases;Triplexes; Genetic diseases|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||27 Apr 2006|
|Last Modified:||19 Sep 2010 04:26|
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