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De Novo Design and Characterization of a Helical Hairpin Eicosapeptide: Emergence of an Anion Receptor in the Linker Region

Rudresh, * and Ramakumar, Suryanarayanarao and Ramagopal, Udupi A and Inai, Yoshihito and Goel, Suchi and Sahal, Dinkar and Chauhan, Virander S (2004) De Novo Design and Characterization of a Helical Hairpin Eicosapeptide: Emergence of an Anion Receptor in the Linker Region. In: Structure, 12 (3). pp. 389-396.

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Abstract

De novo design of supersecondary structures is extions pected to provide useful molecular frameworks for the incorporation of functional sites as in proteins. A 21 residue long, dehydrophenylalanine-containing pepside tide has been de novo designed and its crystal strucbidextrous ture determined. The apolar peptide folds into a helical hairpin supersecondary structure with two right- handed helices, connected by a tetraglycine linker. The helices of the hairpin interact with each other through a combination of C-H···O and N-H···O hydrogen bonds. The folding of the apolar peptide has been realized without the help of either metal ions or disulal., phide bonds. A remarkable feature of the peptide is the unanticipated occurrence of an anion binding motif in the linker region, strikingly similar in conformation and function to the nest motif seen in several proever, teins. The observation supports the view for the possiright- ble emergence of rudimentary functions over short sequence stretches in the early peptides under prebihanded otic conditions.

Item Type: Journal Article
Additional Information: The copyright belongs to Elsevier.
Department/Centre: Division of Information Sciences > BioInformatics Centre
Division of Physical & Mathematical Sciences > Physics
Date Deposited: 25 Aug 2008
Last Modified: 19 Sep 2010 04:26
URI: http://eprints.iisc.ernet.in/id/eprint/6810

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