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Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis- (dipyridoquinoxaline)copper(II) complex

Dhar, Shanta and Reddy, Pattubala AN and Chakravarty, Akhil R (2004) Intramolecular nucleophilic activation promoting efficient hydrolytic cleavage of DNA by (aqua)bis- (dipyridoquinoxaline)copper(II) complex. In: Dalton Transactions (5). pp. 697-698.

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Abstract

The axial aqua bound copper(II) complex $[Cu(dpq)_2- (H_2O)](ClO_4)_2,$ having a planar NN-donor heterocyclic base dipyridoquinoxaline (dpq) as the DNA minor groove binder, shows efficient hydrolytic cleavage of supercoiled DNA in the dark and in the absence of any external reagents, as evidenced from T4 ligase experiments, with a rate of $5.58 \pm 0.4 h^{-1}$ and a rate enhancement of $1.55 \times 10^8.$

Item Type: Journal Article
Additional Information: The copyright belongs to Royal Society of Chemistry.
Department/Centre: Division of Chemical Sciences > Inorganic & Physical Chemistry
Date Deposited: 27 May 2006
Last Modified: 19 Sep 2010 04:27
URI: http://eprints.iisc.ernet.in/id/eprint/6965

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