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The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus

Dixit, NM and Perelson, AS (2006) The metabolism, pharmacokinetics and mechanisms of antiviral activity of ribavirin against hepatitis C virus. In: Cellular and Molecular Life Sciences (CMLS), 63 (7-8). pp. 832-842.

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Abstract

Ribavirin, a broad spectrum antiviral agent, in conjunction with interferon forms the current standard of treatment for hepatitis C virus (HCV) infection in humans. While ribavirin alone fails to induce a significant antiviral response, in combination with interferon, ribavirin dramatically improves the long-term outcome of therapy. The predominant mechanism(s) of ribavirin action against HCV, are yet to be established. In this review, we examine the current status of our understanding of the metabolism, pharmacokinetics and mechanisms of the antiviral activity of ribavirin against HCV, all of which are central to the rational identification of improved treatment protocols.

Item Type: Journal Article
Additional Information: Copytight of this article belongs to Birkhäuser Verlag, Basel.
Keywords: Mutagenesis-treatment response-viral dynamics - mathematical model-monotherapy-combination therapy
Department/Centre: Division of Mechanical Sciences > Chemical Engineering
Date Deposited: 30 May 2006
Last Modified: 19 Sep 2010 04:27
URI: http://eprints.iisc.ernet.in/id/eprint/7103

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