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Improved sensitivity and gradient-enhanced multiplicity edited two-dimensional heteronuclear shift correlation technique

Gowda, Nagana GA (2002) Improved sensitivity and gradient-enhanced multiplicity edited two-dimensional heteronuclear shift correlation technique. In: Chemical Physics Letters, 353 (1-2). pp. 49-54.

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Abstract

A method that combines sensitivity and a gradient-enhanced two-dimensional heteronuclear shift correlation experiment with constant-time evolution during the $t_1$ period is proposed for multiplicity editing of the spectra at natural $^1^3C$ abundance. In the resultant two-dimensional spectrum the cross-peaks of CH and $CH_3$ groups are negative whereas those of $CH_2$ groups are positive in sign. We demonstrate the technique on a small biomolecule. cyclosporin A. It is observed that the sensitivity of the new multiplicity editing experiment (named as CT-PFG-PEP-HSQC) is comparable with that of the conventional PFG-PEP-HSQC experiment and therefore the new scheme can be useful for routine applications.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Department/Centre: Division of Chemical Sciences > Sophisticated Instruments Facility
Date Deposited: 03 Jun 2006
Last Modified: 19 Sep 2010 04:28
URI: http://eprints.iisc.ernet.in/id/eprint/7466

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