Ghosh, Yamuna Krishnan and Gopalanb, Srinivasa R and Kulkarni, GU and Bhattacharya, Santanu (2001) Structure of cholest-5-en-3$\beta$-oxy-5-bromopentane by singlecrystal X-ray diffraction at 130 K. In: Journal of Molecular Structure, 560 (1-3). pp. 345-355.
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Cholest $5-en-3\beta-oxy-5$ bromopentane (1) and cholest $5-en -3\beta-oxy-11$ bromoundecane (2), key precursors for the synthesis of novel cationic amphiphiles based on cholesterol, have been synthesized and characterized by $^1H-NMR$ spectroscopy and Xray crystallography. Thermal disorder and effect of length of the bromoalkyl segment on the crystal structure have been investigated. Possible molecular level explanation of the unusual alternating s-trans gauche conformation of the bromopentyl side chain of (1) has been presented.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||X-ray crystallography;Cholesteryl ether;Thermal disorder;Side-chain|
|Department/Centre:||Division of Chemical Sciences > Organic Chemistry|
|Date Deposited:||15 Jun 2006|
|Last Modified:||19 Sep 2010 04:29|
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