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Widespread occurrence of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene haplotype SVMNT in P. falciparum malaria in India

Vathsala, PG and Pramanik, A and Dhanasekaran, S and Devi, Usha C and Pillai, CR and Subbarao, SK and Ghosh, SK and Tiwari, SN and Sathyanarayan, TS and Deshpande, PR and Mishra, GC and Ranjit, MR and Dash, AP and Rangarajan, PN and Padmanaban, G (2004) Widespread occurrence of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) gene haplotype SVMNT in P. falciparum malaria in India. In: The American Journal of Tropical Medicine and Hygiene, 70 (3). pp. 256-259.

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Abstract

The Plasmodium falciparum chloroquine resistance transporter (Pfcrt) K76T mutation and haplotype (amino acids 72-76) and the P. falciparum multidrug resistance 1 (Pfmdr1) mutation (N86Y) were analyzed as markers of chloroquine resistance in the DNAs of 73 blood samples from patients with P. falciparum malaria in India. Seventy of the 73 DNAs had the Pfcrt K76T mutation. Of these, 66 had the SVMNT haplotype and four had CVIET, the African/Southeast Asian haplotype. Only 20 of 69 DNAs had the Pfmdr1 N86Y mutation. It is surprising that the Pfcrt haplotype in India is predominantly SVMNT, rather than that seen in Southeast Asia. The widespread prevalence of the Pfcrt K76T mutation is a cause for concern.

Item Type: Journal Article
Additional Information: The copyright of this article belongs to American Society of Tropical Medicine and Hygiene.
Department/Centre: Division of Biological Sciences > Biochemistry
Date Deposited: 22 Jun 2006
Last Modified: 19 Sep 2010 04:29
URI: http://eprints.iisc.ernet.in/id/eprint/7679

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