Mishra, Beena and Priyadarsini, KI and Mohan, Hari and Mugesh, G (2006) Horseradish peroxidase inhibition and antioxidant activity of ebselen and related organoselenium compounds. In: Bioorganic and Medicinal Chemistry Letters, 16 (20). pp. 5334-5338.
Restricted to Registered users only
Download (139Kb) | Request a copy
Horseradish peroxidase (HRP) inhibition and glutathione peroxidase (GPx) activities of ebselen and some related derivatives are described. These studies show that ebselen and ebselen ditelluride $(EbTe_2)$ with significant antioxidant activity, inhibit the HRP-catalyzed oxidation reactions. In addition, inhibition of lipid peroxidation and singlet oxygen quenching studies were carried out. Although the inhibition of HRP by ebselen is comparable with that of $EbTe_2$, the inhibitory effect on c-radiation induced lipid peroxidation and the GPx activity of ebselen is found to be much higher than that of $EbTe_2$.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||Ebselen;Antioxidant;Selenium;Horseradish peroxidase;Lipid peroxidation|
|Department/Centre:||Division of Chemical Sciences > Inorganic & Physical Chemistry|
|Date Deposited:||19 Nov 2007|
|Last Modified:||19 Sep 2010 04:32|
Actions (login required)