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Enantiospecific synthesis of (-)-muricatacin from L-(+)- tartaric acid

Prasad, Kavirayani R and Anbarasan, Pazhamalai (2006) Enantiospecific synthesis of (-)-muricatacin from L-(+)- tartaric acid. In: Tetrahedron: Asymmetry, 17 (17). pp. 2465-2467.

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Abstract

Enantiospecific synthesis of (-)-muricatacin, a bio-active lactone comprising of a 5-hydroxyalkylbutan-4-olide structural component has been achieved from L-(+)-tartaric acid. The key step involves a disteroselective reduction of a $C_2$-symmetric 1,4-diketone derived from tartaric acid followed by a selective Grignard reagent addition.

Item Type: Journal Article
Additional Information: Copyright of this article belongs to Elsevier.
Department/Centre: Division of Chemical Sciences > Organic Chemistry
Date Deposited: 30 Nov 2007
Last Modified: 19 Sep 2010 04:33
URI: http://eprints.iisc.ernet.in/id/eprint/9116

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