Bodhini, D and Radha, V and Deepa, R and Ghosh, S and Majumder, PP and Rao, MRS and Mohan, V (2007) The G1057D polymorphism of IRS-2 gene and its relationship with obesity in conferring susceptibility to type 2 diabetes in Asian Indians. In: International Journal of Obesity, 31 (1). pp. 97-102.
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Insulin receptor substrate-2 (IRS-2), one of the major substrates of the insulin receptor, has a crucial role in insulin signalling and in beta cell development and survival. While several polymorphisms have been identified in the IRS-2 gene, the association of the Gly1057Asp polymorphism (G1057D, rs1805097) with type 2 diabetes has been studied in Danish, Finnish, Chinese, Swedish, and German populations, but the results have been inconsistent. A study from eastern Italy reported an association of this polymorphism with lower risk of diabetes in lean people, but with a higher risk in obese people suggesting that there could be a gene environment interaction. A study in Pima Indians also suggested that the presence of obesity could influence the susceptibility of this polymorphism to diabetes.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Nature Publishing Group.|
|Keywords:||IRS-2 gene;G1057D polymorphism;Insulin signalling;Type 2 diabetes;Asian Indians|
|Department/Centre:||Division of Biological Sciences > Biochemistry|
|Date Deposited:||07 Mar 2007|
|Last Modified:||19 Sep 2010 04:34|
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