Venkateswarlu, Divi and Lyngdoh, Duncan RH (1997) Deglycosylation of alkylated nucleosides: a molecular orbital study. In: Journal of Molecular Structure (Theochem), 418 (1). pp. 49-57.
Restricted to Registered users only
Download (719Kb) | Request a copy
The glycoside bond in alkylated nucleosides is known to be more stable for $0^6$ -alkylguanosines and $0^4$ - alkylthymines, and less stable for $N^3$ - and $N^7$ -alkylpurine and $O^2$ - alkylpyrimidine nucleosides. These marked differences have been demonstrated through in vitro acidic hydrolysis and in vivo glycosylase repair. This study examines the relative facility of the deglycosylation reaction for various nucleosides through the use of theoretical indices derived from the semiempirical AM1 SCF-MO methodology, which furnish inferences much in consonance with experiment.
|Item Type:||Journal Article|
|Additional Information:||Copyright of this article belongs to Elsevier.|
|Keywords:||Alkylated nucleosides;Deglycosylation;Molecular orbital calculations;In vitro stability|
|Department/Centre:||Division of Biological Sciences > Molecular Biophysics Unit|
|Date Deposited:||23 Feb 2007|
|Last Modified:||19 Sep 2010 04:35|
Actions (login required)